Biological Safety


OverviewBack to Top

As a major research institution, the UW-Madison must provide assurances that its biomedical laboratory practices are in compliance with state and federal regulations and guidelines.

Office of Biological Safety

At UW-Madison, the Office of Biological Safety (OBS) provides oversight and assistance in assuring compliance with all laws, regulations, and rules governing biomedical laboratory practices and facilities.

The OBS is the administrative office of the Institutional Biosafety Committee (IBC), which reviews research activities involving biologically hazardous materials and/or recombinant DNA molecules/organisms.

GuidelinesBack to Top

Biosafety Protocols

OBS requires submission of a Biosafety Protocol for research activities involving:

  • Microbiological agents infectious to humans and/or animals.
  • Exotic plants, animals, and microbes (e.g., nonindigenous plants or insect pathogens, or biological control agents)
  • Potentially infectious materials derived from humans (e.g., established cell lines) and from animals, including their blood, tissues, and cell lines, for which a reasonable potential for transmission of zoonotic agents exists, e.g., wild-trapped animals, sheep, and rhesus macaques.
  • Select agents. CDC regulates these microbes and toxins due to their threat to public health and safety.
  • Recombinant DNA molecules and recombinant DNA-containing organisms or cell cultures which are subject to the NIH Guidelines for Research Involving Recombinant DNA Molecules. Please contact OBS about requirements for protocols involving human gene therapy trials. (Many rDNA experiments are considered to be low-risk yet still are subject to the Guidelines for Research Involving Recombinant DNA Molecules.)
  • Prions: proteins that reproduce independently and cause spongiform diseases (chronic wasting disease in deer, elk; mad cow disease in cattle; Creutzfeld-Jakob disease in humans)

Investigator Requirements

Investigators planning to work with materials/organisms listed above must:

Submitting ProtocolsBack to Top

Protocol Guidance/Forms

  • Forms and instructions are available from the OBS website: Biosafety Protocol Instructions and Forms
  • New and renewal protocols must be submitted through Bio-ARROW
  • Some protocols do not require review by the IBC; these are reviewd by OBS staff on a rolling basis
  • For protocols that require IBC review, protocols must be submitted at least 1 month prior to an IBC meeting (typically held on the first Wednesday of each month)
  • Protocols are approved for a maximum of 3 years. Protocols for longer projects must be renewed every 3 years.
  • For additional information, visit the OBS Biosafety Protocol Page.

Protocol Amendments

In certain situations, a protocol may need to be changed during the course of a project. There are three types of changes, or amendments, to protocols:

  • Administrative Amendments are needed when funding sources are added or changed.
  • Personnel Amendments are needed when lab personnel are added or removed.
  • Protocol Amendments are needed when the scope of work changes.
    Examples include changes in research elements, microbes utilized, and/or laboratory location or room updates.

Amendments can be submitted online through Bio-ARROW. Note: During transition process not every protocol will need to convert to online Bio-ARROW right away. If you need to make an amendment contact Biosafety for more information, phone: 608-263-2037; email: biosafety@fpm.wisc.edu

TrainingBack to Top

Required Training

All lab personnel (including PIs and graduate students) involved in biological research must complete the training courses below within 30 days of beginning work on campus.

  • Biosafety 101: Risk Assessment
  • Biosafety 104: Safe Use of Sharps
  • Biosafety 201: NIH Guidelines

These courses are completed online via Learn@UW, and are available 24 hours a day, 7 days a week. A valid UW-Madison NetID is needed in order to access the courses.

Instructions for completing courses: OBS Biosafety Training Courses

Optional Training

Additional biosafety courses are available via Learn@UW to all UW faculty, staff, and students. See OBS Biosafety Training Courses for more information.

ResourcesBack to Top

UW-Madison Campus Resources
Biosafety Protocol Instructions and Forms OBS biosafety protocol instructions and forms
First Report of Exposure/Release Form Online form for reporting potential exposures to or releases of organisms/biological toxins
UW Madison Office of Biological Safety (OBS) Office of Biological Safety main site
UW Madison Select Agent Program Forms, links, and training information for researchers using Select Agents
Biosafety Guidebooks
Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition CDC biosafety guidebook
Guidelines for waste disposal and campus services
OBS waste disposal guidebook
NIH Guidelines for Research Involving Recombinant DNA Molecules
External Resources
CDC Regulation of Select Agents and Toxins Information on the regulation of Select Agents, from the Centers for Disease Control website
USDA Animal and Plant Health Inspection Service (APHIS) Information on regulations and permits for import/export and transport of exotic plants, animals, and microbes (e.g., nonindigenous plants or insect pathogens, or biological control agents).

ContactsBack to Top

General Compliance Questions

Cheryl Deering
CALS Research Compliance Specialist
(608) 262-2536
cdeering@cals.wisc.edu

Office of Biological Safety

(608) 263-2037
biosafety@fpm.wisc.edu

For individual OBS staff contacts, see Office of Biological Safety Staff page

Comments are closed.